Jul 25, 2021 · Pemphigus vulgaris is an autoimmune blistering disease. The keratinocytes are cemented together at unique sticky spots called desmosomes. In pemphigus vulgaris, immunoglobulin type G (IgG) autoantibodies bind to a protein called desmoglein 3 (dsg3), which is found in desmosomes in the keratinocytes near the bottom of the epidermis.

Pemphigus vulgaris is a chronic vesiculobullous skin disorder characterised by autoantibodies against desmoglein 3, which is a component of the desmosome (an intracellular adhesion molecule). Disruption of keratinocyte adhesion leads to superficial blistering and erosion affecting the skin and/or mucous membranes. Histology of pemphigus vulgaris

DermNet pages about pemphigus. Benign familial pemphigus Brazilian pemphigus foliaceus Drug-induced pemphigus Endemic pemphigus foliaceus Familial benign pemphigus pathology IgA pemphigus Paraneoplastic pemphigus Paraneoplastic pemphigus pathology Pemphigus foliaceus Pemphigus foliaceus pathology Pemphigus vulgaris Pemphigus vulgaris images

Pemphigus vulgaris is more common in patients of Ashkenazi Jewish descent and those of Mediterranean origin. Men and women are equally affected, with the mean age of onset being 50 to 60 years. However, it may also affect children and the elderly. Clinical presentation of oral pemphigus. Pemphigus vulgaris involves mucosal surfaces in 50–70% ...

Pemphigus foliaceus presents with erythematous, scaly or crusted plaques. Vesicles, bullae and erosions may or may not be present. It most commonly affects the trunk. The oral mucosa is not involved. Non-thiol drugs most commonly cause pemphigus vulgaris. Pemphigus vulgaris presents with painful flaccid vesicles and bullae.

Pemphigus vulgaris is a rare autoimmune disease that is characterised by painful blisters and erosions on the skin and mucous membranes, most commonly inside the mouth. View pictures of pemphigus vulgaris in the gallery below.

Pemphigus foliaceus is a rare relatively benign form of pemphigus. In New Zealand pemphigus foliaceus is more often encountered than its more serious relative pemphigus vulgaris, although worldwide pemphigus vulgaris is more common. Pemphigus foliaceus is characterised by blistering lesions on otherwise healthy-looking

PNP is a rare autoimmune bullous disease variant; it is the least common but most serious form of pemphigus, accounting for 3–5% of all cases. Though PNP most commonly develops in adults between 45–70 years of age with equal male and female sex predilection , …

Intercellular space staining pattern (chicken-wire), pemphigus vulgaris. Intercellular space staining pattern (chicken-wire), pemphigus foliaceus. Linear IgG deposition on basement membrane zone, bullous pemphigoid. Linear IgA deposition on basement membrane zone, linear IgA bullous dermatosis. Vascular staining pattern in dermal vessels for IgM.

Pemphigus vulgaris; Pemphigus foliaceus; Pemphigus vulgaris is potentially fatal; it usually presents with acute or subacute extensive oral ulceration followed by widespread cutaneous denudation. It appears to be particularly common in middle …