Adipose tissue macrophages (ATMs) comprise resident macrophages present in adipose tissue. Besides adipocytes, adipose tissue contains the stromal vascular fraction (SVF) of cells that includes pre-adipocytes, fibroblasts, vascular endothelial cells, and …

Nov 16, 2020 · Tang, L. et al. Sympathetic nerve activity maintains an anti-inflammatory state in adipose tissue in male mice by inhibiting TNF-α gene expression in macrophages.

An adipose tissue macrophage is a key factor in obesity-induced insulin resistance by regulating a series of insulin-related and inflammatory factor-related signaling pathways through paracrine interactions between adipocytes and macrophages.

The adipose tissue macrophage (ATM) population is a compound system of embryonic and infiltrating monocyte-derived macrophages with the ability of self-renewal.

Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders. In this review, we aim to present the most recent research on ...

Oct 23, 2023 · This Review provides state-of-the-art understanding of adipose tissue macrophages and T cells and discusses how their unique niche can help us to better understand diversity in leukocyte...

Dec 1, 2022 · Lipid Associated Macrophage (LAM) adipose tissue macrophages (ATMs) are the dominant subtype induced by obesity in mice. LAM ATMs in humans can be found in lean adipose tissue and their induction with obesity or metabolic disease is not prominent.

Adipose tissue macrophages (ATMs) represent the most abundant class of leukocytes in AT and are involved in the regulation of several regulatory physiological processes, such as tissue remodeling and insulin sensitivity.

Meanwhile, adipose tissue macrophages also play a beneficial role in maintaining adipose tissue homeostasis by regulating angiogenesis, facilitating the clearance of dead adipocytes, and promoting mitochondrial transfer.

Jun 9, 2022 · Many macrophages can be recruited by various cytokines secreted by adipose tissue. The recruited macrophages further secrete various inflammatory factors to act on adipocytes, and the interaction between the two leads to chronic inflammation.