Typhoid fever, also known simply as typhoid, is a disease caused by Salmonella enterica serotype Typhi bacteria, also called Salmonella Typhi. [2] [3] Symptoms vary from mild to severe, and usually begin six to 30 days after exposure.[4] [5] Often there is a gradual onset of a high fever over several days. [4]This is commonly accompanied by weakness, abdominal pain, …

These specialist pathogens, collectively referred to as typhoidal Salmonella serovars, are the causative agents of enteric fever (also known as typhoid or paratyphoid fever if caused by serovar Typhi or Paratyphi, respectively).

Apr 16, 2021 · Infections caused by Salmonella enterica serotype Typhi (S. Typhi) are often characterized by insidious onset of sustained fever, headache, malaise, anorexia, relative bradycardia, constipation or diarrhea, and non-productive cough. However, mild and atypical infections may occur.

Travelers to destinations beyond North America, Western Europe, Australia and New Zealand, and high-income countries in Asia e.g., Hong Kong, Japan, and Singapore are at risk for typhoid fever, the clinical disease caused by Salmonella enterica …

Salmonella enterica serovar Typhi (S. Typhi) is a Gram-negative pathogen that causes typhoid fever in humans. Though many serotypes of Salmonella spp. are capable of causing disease in both humans and animals alike, S. Typhi and S. Paratyphi are common in human hosts only.

Feb 11, 2016 · Salmonella enterica serovar Typhi is a gram-negative, rod-shaped facultative anaerobe that only infects humans. It is unclear to scientists as to why this pathogen does not infect other organisms and has such a selective host behavior.

Abstract. Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic areas. Greater understanding of host–pathogen interactions during Salmonella infection should facilitate the development of improved vaccines to combat typhoid and nontyphoidal Salmonellosis.

Salmonella enterica serovar Typhi, the cause of typhoid, is host restricted to humans. S. Typhi has a monophyletic population structure, indicating that typhoid in humans is a relatively new disease.

Genomic analysis revealed 3 independent introductions of Salmonella Typhi H58 with reduced fluoroquinolone susceptibility into Chile. Our findings highlight the utility of enhanced genomic surveillance for typhoid fever in this region.

Evidence gathered through genomics and functional studies using the mouse and in vitro cell systems, together with clinical investigations, has provided insight into the mechanisms that underpin the pathogenesis of human typhoid and host restriction.