FIGURE 3. Targeting adhesion molecules in melanoma anoikis resistance. A range of integrins, as well as N-cadherin, and their downstream signalling pathways, including FAK (green), Mitogen-Activated ...

Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...

In malignant melanoma, extracellular stimulus signals are transmitted ... regulation of tumor formation by participating in the EMT, Hippo, AKT, MAPK, and other related signaling pathways. In multiple ...

The lab of The Wistar Institute's Jessie Villanueva, Ph.D., has identified a new strategy for attacking treatment-resistant ...

As part of The Wistar Institute's Melanoma Research Center, the Villanueva lab pursues new ways to overcome the challenge of melanoma drug resistance. In this paper, the group took aim at melanomas ...

The lab of The Wistar Institute's Jessie Villanueva, Ph.D., has identified a new strategy for attacking treatment-resistant melanoma: inhibiting the gene S6K2. .

As part of The Wistar Institute’s Melanoma Research Center, the Villanueva lab pursues new ways to overcome the challenge of melanoma drug resistance. In this paper, the group took aim at melanomas ...

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers ...

which has made it a priority of melanoma researchers. Previous research has indicated that MAPK inhibitors could be a potential therapy for NRAS MUT melanoma. However, on their own, MAPK ...