SAMURI uses S-adenosylmethionine (SAM) for these modifications, unlike natural riboswitches that bind SAM without catalysis. Understanding SAMURI's structure aids in developing RNA-based therapeutics.

Some RNA molecules act as enzymes, called ribozymes, that facilitate essential chemical reactions. A notable ribozyme, SAMURI, has been analyzed by researchers at the University of Würzburg (JMU), who ...