We speculate that this response was mediated by enhanced ERK1/2 activity, which was compensatory for p38 inhibition. Indeed, we have previously noted that the p38 pathway inhibits ERK1/2 ...

The classical pathway is initiated by the interaction of C1 with IgG ... upregulating the expression of proinflammatory mediators by activating ERK1/2 and releasing extracellular ATP in monocytes or ...

An oft-repeated message is that primary aldosteronism is not rare; it is quite common. An equally urgent message is that ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

We sell different types of products and services to both investment professionals and individual investors. These products and services are usually sold through license agreements or subscriptions ...

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

Lung cancer is a particularly challenging form of cancer. It often strikes unexpectedly and aggressively with little warning, ...

Contrary to prior data, this study shows that neither eosinophils nor STAT6-mediated IL-4/IL-13 signaling contribute ...

However, the Nintendo Switch 2 will not arrive in your mailbox for at least the next few months. While we have a better idea of what it looks like, we still have to rely on leaks and rumors for ...

Some eight years since the Nintendo Switch was released, we have finally got an official look at the Nintendo Switch 2. In a rather brief trailer, Nintendo showed off its next-generation gaming ...