Our goal is to unravel the early events that create the endosome/phagosome, a membrane-bound compartment that is moved by motors either to lysosomes ... how viruses and bacteria exploit it to enter ...

The signal 1 or the priming signal is mediated by pathogenic PAMPs from bacteria or virus, or sterile DAMPs resulting ... in response to cathepsin B release from damaged lysosomes or in response to ...

Antibiotics are indispensable for treating bacterial infections. But why are they sometimes ineffective, even when the ...

Phages are viruses that attack bacteria by injecting their DNA, then usurping bacterial machinery to reproduce. Eventually, ...

A microbe found in the lower part of the gut that is associated with good health has been comprehensively analyzed and found to have a focused diet breaking down sugars locked away in mucus, according ...

This important study presents compelling observational data supporting a role for transcription and polysome accumulation in the separation of newly replicated bacterial chromosomes. The study is ...

Light and electron microscopy have distinct limitations. Light microscopy makes it difficult to resolve smaller and smaller features, and electron microscopy resolves small structures, but samples ...

Biofilms are clusters of microorganisms that stick to non-biological surfaces, such as rocks in a stream, as well as to surfaces on plants (roots) or in animals (epithelium). These clusters are ...

Disinfectants induce oxidative damage in bacteria, but a single mutation triggers the expression of genes that help the ...

lysosomes and nuclei, and specific signaling pathways are rapidly activated, first by interactions of HAMLET with the cell membrane and subsequently after HAMLET internalization. Therapeutic ...

The parent molecule that we've designed this on is called Stefin A, a naturally occurring human protease inhibitor found in the cell lysosome. It's a very small protein and its main function is to ...

The term programmed cell death (PCD) was coined in 1965 to describe the loss ... we subcloned a portion of the BBH1 cDNA into a bacterial expression vector and observed that it was labeled on Western ...