That prospect is already chilling investment in drug research, particularly in small-molecule drugs. This category of medicines, which are generally chemically synthesized, includes everything ...

"Small-molecule" drugs are up for price caps nine years after hitting the market, versus 13 for large-molecule biologics. This discrepancy could wallop cancer research. It can take drugmakers 15 ...

so searches are constrained to a relatively small pool. CADD is an iterative process requiring a series of optimizations. “Once you find a molecule which binds to your target, you optimize it to ...