Next, they transduced CD34 + cells obtained from the cord blood of newborns with sickle cell disease. The cells were transduced with a lentiviral vector delivering the gene encoding the anti ...

The US biotech said the suspected serious adverse reaction reported in the phase 1/2 study of LentiGlobin gene therapy for sickle cell disease was unlikely to be related to the virus vector used ...

with the intention of outcompeting the mutated β-sickle chains and increasing fetal hemoglobin formation. Comparative studies of vector encoding γ(G16D) versus unmodified γ-globin show a higher ...