Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

Mitochondria play a crucial role in cellular energy production, and their dysfunction has long been linked to metabolic ...

The presence of mitochondrial DNA with deletions—the loss of fragments of DNA sequence—in cerebrospinal fluid could be an early marker of severe brain disease and an initial link in the whole ...

Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use the insulin ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

New York: Mitochondria, that produce energy for the cell, holds the key to curing diabetes, researchers have learned.

Oxidative stress and DNA damage are also implicated in Parkinson's disease. Increased levels of oxidative stress as well as expression of the mitochondrial BER enzyme 8-oxoguanosine DNA ...

Recent years have seen considerable advances in the description and understanding of mitochondrial DNA (mtDNA ... by the lack of a mouse model of mtDNA disease: direct manipulation of the mtDNA ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...

Mitochondrial damage is common in metabolic diseases like Diabetes, affecting insulin production and function in patients. Diabetics’ insulin-producing β-cells have abnormal mitochondria, impairing ...