"Lysosomes are organelles that are involved ... suggesting that this protective function of STING is important for healthy ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...

The core will provide: Robust and reproducible quantitative proteomic analysis of purified lysosomes to enable the study of the ... and Data Integration Core to be integrated into the Aging- and ...

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say. Holly Barker is a freelance journalist ...

Tan hopes these insights will support therapeutic development, as chronic activation of STING is seen in aging and neurodegenerative diseases like Alzheimer’s disease, which involve impaired lysosome ...

De Duve named these new organelles "lysosomes" to reflect their lytic nature. That same year, Alex Novikoff from the University of Vermont visited de Duve´s laboratory. An experienced ...

Once fats are broken down in the lysosome, they serve several important roles in the cell. One is membrane repair and maintenance. The broken-down fat components, such as phospholipids and ...

The ER, Golgi apparatus, and lysosomes are all members of a network of membranes, but they are not continuous with one another. Therefore, the membrane lipids and proteins that are synthesized in ...

The Longevity India Conference 2025 - Rise for Healthy Aging, hosted at the Indian Institute of Science (IISc), concluded its final day with impactful discussions on longevity science. The discussions ...