Feng Wei at the Institute of Biophysics, Chinese Academy of Sciences, has made significant strides in understanding the BORC complex, a key player in lysosome transport and localization.

The biotech is focusing on precision, small-molecule medicines that work via a process known as cellular clearance by activating the lysosome, sometimes referred to as the cell’s recycling and ...

During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases. Survival during fasting requires release of adipose tissue ...

Early work revealed that TFEB is highly effective in ameliorating tau/NFT pathology and rescuing cognitive impairment and neurodegeneration. TFEB targets only the aberrant tau species and this ...

The autophagosome then fuses with another type of vesicle called lysosome. The fused stage is called autolysosome. The autolysosome ultimately matures into lysosome, where the waste is degraded by ...

The lab also studies mechanisms that regulate autophagy protein and lysosome function in endocytic trafficking and nutrient homeostasis. Cell biologist Michael Overholtzer explores genes that make ...

Here, the authors identify that the TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis is essential for lysosome degradation, with FBXO3 functioning in lysosome integrity. Tao et al. show that epidermal growth ...