They classified acute myeloid leukemia cells by their resemblance to gene expression of stem cells at different life stages, discovering that the normal stem cell age most reflective of leukemia ...

Researchers observed an increase in both CXCR4 and CD5 levels as the cells progressed to later stages of the cell cycle, particularly in the S/G2/M phases.

One common form of leukemia is acute myeloid leukemia ... this process ensures that immune cells do not inadvertently attack normal body cells, thereby causing major damage.

B-cell prolymphocytic leukemia (B-PLL) is a rare, aggressive type of leukemia that progresses rapidly. People with B-PLL typically have a less favorable outlook. However, new targeted treatments ...

UIC researchers have redesigned asparaginase, a key leukemia treatment, to reduce severe side effects like liver damage and ...

Targeted therapies for high-risk leukemia in children have yet ... specifically because they eliminate cancer cells without affecting normal cells. This nuance is crucial for the development ...

Changes in Blood Cell Production Over the Lifetime Could Impact Leukemia Outcomes Dec. 5, 2024 — The first comprehensive map of the dramatic changes that take place in the blood system over the ...

In T cell cancers such as T cell lymphoblastic leukemia (TLL), this challenge arises from fratricide, CAR T cell self-destruction. 1–3 CAR T cells often share the same receptors as malignant T cells, ...

MB-105, a first-in-class CD5-targeted CAR T-cell therapy, received FDA orphan drug designation for relapsed/refractory T-cell lymphoma.

Upon analyzing the levels of 3,000 genes in a T cell leukemia cell line grown in high or low levels ... and the cancer cells died. Under normal conditions, a cell that runs out of pyrimidines would ...

Most people live with CLL much longer than with other cancers or other types of leukemia. CLL and ALL begin in the bone marrow, where blood cells are usually made. Specifically, it starts in a ...

University of Illinois Chicago scientists have redesigned a treatment for the most common pediatric leukemia to eliminate its ...