With the final step in HIF pathway established, scientists began to explore ways to utilize it. Because the hypoxia response is present across all tissues and cell types, the HIF pathway drives ...

Hypoxia can drive the metastatic phenotype ... preclinical studies of molecular-targeted agents that inhibit cancer cell signalling pathways are rarely conducted under varied microenvironmental ...

Van Meir's research examines how genetic alterations and hypoxia induce changes in cell biology that promote tumor formation with particular emphasis on heterotypic cell-cell signaling ... the hypoxia ...