Translocations generate novel chromosomes, but are often linked to disorders like infertility and cancer. How do these new chromosomes generate problems, and how are they detected? Translocations ...

(Because the translocations responsible for DS can be inherited, this form of the disease is sometimes referred to as familial DS.) In these cases, a segment of chromosome 21 is transferred to a ...

Chromosomal translocations occur in leukemias, lymphomas, sarcomas and some epithelial tumors and some generate unique fusion proteins. These translocation products may provide tumor-specific ...

One specific change they analyzed is the translocation of human PAR2 (pseudoautosomal region 2), a swapping of the tips of our X and Y chromosomes. This occurred relatively recently in primate ...

A population bottleneck approximately 900,000 years ago is thought to coincide with genomic rearrangements, the fusion of chromosome 2 and the translocation of the pseudoautosomal region 2 (PAR2).

With PacBio’s innovative multiomic solutions, researchers identified a chromosome X;13 balanced translocation disrupting four key genes—each through a unique molecular mechanism. "This study ...