Almost 35% of drugs approved by the Food and Drug Administration work by targeting G protein-coupled receptors (GPCRs), proteins embedded in cell membranes that allow cells to communicate with ...

Because membrane receptors interact with both extracellular signals and molecules within the cell, they permit signaling molecules to affect cell function without actually entering the cell.

Our News & Views discussed a recent paper 6 that clearly stated that the existence of a putative membrane ... receptor couples to a common intracellular signaling pathway in four different cells ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

To switch on the cell death signal, just 15% of all CD95 receptors on the cell membrane need to bind in twos or threes around ...

In the cell membrane, TRPM8 acts as a receptor for cold, enabling humans to sense cold. Researchers at Ludwig-Maximilians-Universitat have developed a ...

The fatty membrane surrounding every living cell is a vibrant environment where countless biological processes take place.

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

Glycoproteins typically bind to receptors on the membrane of a host cell. Viruses that do not bud from the host cell membrane do not have an envelope, so they are called “naked” or ...

Adhesion G protein-coupled receptors (GPCRs) are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for ...