Fire officials said three people suffered injuries not considered life-threatening and were taken to an area hospital.
The crash happened just before 9:30 p.m. just south of Central Ave. on northbound lanes of I-15, according to CHP officers.
A man is dead after a rollover crash on Interstate 15 at mile marker 101 on Sunday, according to the Nevada Highway Patrol.
Two early morning crashes have snarled traffic on Interstate 15 and Interstate 805 near the Interstate 8 connectors, causing backups though uptown San Diego ahead of the morning commute.