Santa Isabel is a town and municipality of Puerto Rico located in the southern coast of the island, south of Coamo; east of Juana Díaz; and west of Salinas. Santa Isabel is spread over 7 barrios and Santa Isabel Pueblo. It is the principal city of the Santa Isabel Micropolitan Statistical Area and is part of the Ponce-Yauco-Coamo Combined Statistical Area.
Settled: 1801
Founded: October 5, 1842
Founded by: Don Juan de la Cruz, and Antonio Vélez