Big Creek is a village in Calhoun County, Mississippi, United States. The population was 154 at the 2010 census. Big Creek is located in southwestern Calhoun County at 33°50′49″N 89°24′45″W / 33.84694°N 89.41250°W, 6 miles west of Calhoun City and slightly over a mile west of Big Creek, a tributary of the Yalobusha River, which in turn is a tribut…Big Creek is a village in Calhoun County, Mississippi, United States. The population was 154 at the 2010 census. Big Creek is located in southwestern Calhoun County at 33°50′49″N 89°24′45″W / 33.84694°N 89.41250°W, 6 miles west of Calhoun City and slightly over a mile west of Big Creek, a tributary of the Yalobusha River, which in turn is a tributary of the Yazoo River.
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